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Related Experiment Video

Updated: Dec 7, 2025

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Changes in splenic uptake pattern associated with X-ray irradiation.

Fernando P de Faria1,2, Andy Petroianu2, Paula P Campos3

  • 1Departamento de Energia Nuclear, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.

Heliyon
|September 30, 2020
PubMed
Summary
This summary is machine-generated.

High-energy X-rays used in radiotherapy enhance splenic uptake by marginal zone macrophages. This radiation does not cause significant morphological changes, necrosis, or apoptosis in splenic tissue.

Keywords:
Cancer researchCell biologyHigh-energy X-raysImmune responseMacrophageMarginal zoneOncologyPhagocytosisSpleenUptake function

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Area of Science:

  • Radiology
  • Immunology
  • Histology

Background:

  • The spleen plays a crucial role in filtering blood and immune surveillance.
  • Radiation therapy, particularly using high-energy X-rays, is a common cancer treatment.
  • Understanding the effects of radiation on splenic function is important for managing treatment side effects and patient outcomes.

Purpose of the Study:

  • To investigate the impact of high-energy X-ray irradiation on the splenic uptake function.
  • To evaluate changes in macrophage activity within the spleen following irradiation.

Main Methods:

  • Wistar rats were divided into control and irradiated groups (24h and 48h post-irradiation).
  • Animals received 8 Gy of X-ray irradiation to the abdominal region.
  • Colloidal carbon solution was injected, and spleens were analyzed histologically to quantify carbon uptake by macrophages.

Main Results:

  • Irradiated rats showed enhanced carbon particle uptake by macrophages in the splenic marginal zone.
  • No significant splenic parenchyma disorder or necrosis was observed.
  • Apoptotic events were rare and not significantly different between control and irradiated groups.

Conclusions:

  • High-energy X-rays modify splenic clearance mechanisms, increasing uptake in the marginal zone.
  • The observed radiation dose did not induce significant morphological damage, necrosis, or apoptosis in splenic tissue.
  • These findings suggest a functional alteration of splenic macrophages without overt tissue destruction following irradiation.