Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Different binding forms of cadmium--implications for distribution and toxicity.

G F Nordberg, M Nordberg

    Journal of UOEH
    |March 20, 1987
    PubMed
    Summary

    Cadmium exposure can cause kidney tubule damage by accumulating in renal cells. This damage occurs when non-metallothionein bound cadmium reaches toxic levels, a process understood primarily through animal studies.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Evaluation of COVID-19 screening for international travellers.

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2022
    Same author

    Longitudinal Flow Decorrelations in Xe+Xe Collisions at sqrt[s_{NN}]=5.44  TeV with the ATLAS Detector.

    Physical review letters·2021
    Same author

    Search for Dark Matter Produced in Association with a Dark Higgs Boson Decaying into W^{±}W^{∓} or ZZ in Fully Hadronic Final States from sqrt[s]=13  TeV pp Collisions Recorded with the ATLAS Detector.

    Physical review letters·2021
    Same author

    Medium-Induced Modification of Z-Tagged Charged Particle Yields in Pb+Pb Collisions at 5.02 TeV with the ATLAS Detector.

    Physical review letters·2021
    Same author

    Observation and Measurement of Forward Proton Scattering in Association with Lepton Pairs Produced via the Photon Fusion Mechanism at ATLAS.

    Physical review letters·2021
    Same author

    Search for Heavy Resonances Decaying into a Photon and a Hadronically Decaying Higgs Boson in pp Collisions at sqrt[s]=13  TeV with the ATLAS Detector.

    Physical review letters·2021

    Area of Science:

    • Toxicology
    • Environmental Health
    • Renal Physiology

    Background:

    • Cadmium (Cd) exposure is a significant environmental health concern.
    • Renal tubular damage is a known consequence of chronic cadmium exposure.
    • Understanding the precise mechanisms of cadmium-induced nephrotoxicity is crucial for risk assessment.

    Purpose of the Study:

    • To summarize current knowledge on the mechanisms of cadmium-induced renal tubular damage.
    • To present a quantitative model for human exposure and renal damage relationships.
    • To highlight data gaps in human studies regarding cadmium nephrotoxicity.

    Main Methods:

    • Review and synthesis of existing data on cadmium uptake and transport.
    • Description of metallothionein's role in cadmium detoxification and toxicity.
    • Development of a quantitative model based on animal and cellular data, extrapolated to humans.

    Main Results:

    • Cadmium is absorbed, transported via plasma proteins (albumin, metallothionein), and taken up by renal tubules.
    • Metallothionein in renal lysosomes releases cadmium, which can then cause cellular damage.
    • Renal damage occurs when non-metallothionein bound cadmium concentration exceeds a threshold.

    Conclusions:

    • The proposed mechanism of renal tubular damage by cadmium involves intracellular accumulation and release from metallothionein.
    • A quantitative model for human exposure is proposed, but requires more human data for validation.
    • Further human epidemiological and toxicological studies are needed to refine understanding and risk assessment of cadmium nephrotoxicity.

    Related Experiment Videos