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Updated: Dec 7, 2025

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
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Cobalt-Catalyzed C(sp2)-C(sp3) Suzuki-Miyaura Cross Coupling

Jacob R Ludwig1, Eric M Simmons2, Steven R Wisniewski2

  • 1Department of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.

Organic Letters
|September 30, 2020
PubMed
Summary

A new cobalt-catalyzed Suzuki-Miyaura coupling method enables C(sp2)-C(sp3) bond formation between aryl boronic esters and alkyl bromides. This efficient reaction offers broad scope for diverse substrates, advancing organic synthesis.

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