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Directed vertical cell migration via bifunctionalized nanomaterials in 3D step-gradient nanocomposite hydrogels
Andisheh Motealleh1, Nermin S Kehr
1Physikalisches Institute and Center for Soft Nanoscience, Westfälische Wilhelms-Universität Münster, Busso-Peus-Strasse 10, 48149 Münster, Germany. seda@uni-muenster.de.
Biomaterials Science
|September 30, 2020
Summary
Researchers developed novel 3D-printed nanocomposite scaffolds with vertically increasing nanomaterials. These scaffolds guide healthy cell migration while inhibiting cancer cell growth, crucial for tissue regeneration and cancer therapy.
Area of Science:
- Biomaterials Science
- Cell Biology
- Nanotechnology
Background:
- Directional cell migration is vital for development, regeneration, and immunity.
- Existing gradient biomaterials primarily focus on horizontal (XY) cell migration.
- Vertical (XZ) cell migration is critical for processes like wound healing and metastasis.
Purpose of the Study:
- To design and fabricate novel step-gradient nanocomposite (NC) scaffolds for studying vertical (XZ) cell migration.
- To investigate the influence of bifunctional nanomaterials (NMs) on cell behavior in a 3D environment.
- To explore the potential of these scaffolds for targeted drug delivery and cancer therapy.
Main Methods:
- Fabrication of step-gradient NC scaffolds using 3D printing with varying concentrations of bifunctional NMs.
- Incorporation of pH-responsive bifunctional NMs for sustained release of bioactive molecules.
- Assessment of healthy and cancer cell migration, viability, and growth within the scaffolds.
Main Results:
- Vertically increasing concentrations of bifunctional NMs effectively influenced cell migration in the XZ plane.
- Bifunctional NMs enhanced healthy cell viability and promoted their migration in the XZ plane.
- Simultaneous inhibition of cancer cell migration and growth was observed due to pH-responsive drug release.
Conclusions:
- Novel 3D-printed step-gradient NC scaffolds can effectively control vertical cell migration.
- Bifunctional NMs offer a dual therapeutic approach: promoting healthy cell function and inhibiting cancer progression.
- These scaffolds hold promise for advanced applications in tissue engineering and oncology.
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