Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Anatomy of the Intestines01:23

Anatomy of the Intestines

86.0K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
86.0K
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

531
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
531

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Trends in the Mortality and Death of Periviable Preterm Infants in the United States, 2011 to 2020.

American journal of perinatology·2024
Same author

Impact of COVID-19 in pregnancy on maternal and perinatal outcomes during the Delta variant period: a comparison of the Delta and pre-delta time periods, 2020-2021.

Maternal health, neonatology and perinatology·2024
Same author

Predicting Lead-Time RSV-Related Pediatric Hospitalizations From Historic Google Trend Search.

Hospital pediatrics·2023
Same author

Association between Neonatal Abstinence Syndrome and Congenital Anomalies in the United States.

American journal of perinatology·2022
Same author

Neurodevelopmental outcomes of extremely preterm infants fed an exclusive human milk-based diet versus a mixed human milk + bovine milk-based diet: a multi-center study.

Journal of perinatology : official journal of the California Perinatal Association·2022
Same author

Trends and Resource Use for Kernicterus Hospitalizations in the United States.

Hospital pediatrics·2022
Same journal

A Renewed Call to Action for Breastfeeding Support: Let's Collaborate.

Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine·2026
Same journal

Improving Access to Hospital-Grade Breast Pumps for Women with Infants in the Neonatal Intensive Care Unit.

Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine·2026
Same journal

Examining Relationships Between Multiple Adverse Social Determinants of Health, Maternal Depressive Symptoms, Timing of Solid Food Introduction, and Breastfeeding Duration Among Black or African American Women.

Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine·2026
Same journal

Letter to the Editor Regarding "Impact of Oromotor Stimulation on Transition from Gavage to Full Oral Feeding in Preterm Neonates: A Randomized Controlled Trial".

Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine·2026
Same journal

Impact of Integrated Continuous Team Midwifery Care on Breastfeeding Success within the Iranian Health System: A Randomized Controlled Trial.

Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine·2026
Same journal

A Full Plate-Reflections from an ABM Founder.

Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine·2026
See all related articles

Related Experiment Video

Updated: Dec 7, 2025

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers
09:36

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers

Published on: July 28, 2022

2.5K

Does Human Milk Fortifier Affect Intestinal Inflammation in Preterm Infants?

Harshit Doshi1, Shachee Pandya1, Champa N Codipilly1

  • 1Division of Neonatal-Perinatal Medicine, Cohen Children's Medical Center, Lilling Family Neonatal Research Lab, Feinstein Institutes for Medical Research, Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, New York, USA.

Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine
|September 30, 2020
PubMed
Summary
This summary is machine-generated.

Newer protein hydrolysate-based human milk fortifiers do not increase fecal calprotectin, a marker of intestinal inflammation, in preterm infants. This suggests these fortifiers are safe for sensitive infant guts.

Keywords:
NICUcalprotectinhuman milk fortifierintestinal inflammationpreterm infants

More Related Videos

Breast Milk Enhances Growth of Enteroids: An Ex Vivo Model of Cell Proliferation
09:02

Breast Milk Enhances Growth of Enteroids: An Ex Vivo Model of Cell Proliferation

Published on: February 15, 2018

19.8K
A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
08:50

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

4.1K

Related Experiment Videos

Last Updated: Dec 7, 2025

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers
09:36

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers

Published on: July 28, 2022

2.5K
Breast Milk Enhances Growth of Enteroids: An Ex Vivo Model of Cell Proliferation
09:02

Breast Milk Enhances Growth of Enteroids: An Ex Vivo Model of Cell Proliferation

Published on: February 15, 2018

19.8K
A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
08:50

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

4.1K

Area of Science:

  • Neonatal Nutrition
  • Gastroenterology
  • Pediatric Research

Background:

  • Fecal calprotectin is a key indicator of intestinal inflammation, often elevated with intact protein fortifiers in preterm infants.
  • Hydrolyzed protein fortifiers represent a newer approach to nutritional support, potentially mitigating inflammatory responses.

Purpose of the Study:

  • To evaluate fecal calprotectin levels in preterm infants before and after the introduction of human milk fortified with hydrolyzed protein.
  • To determine if hydrolyzed protein fortifiers are associated with increased markers of intestinal inflammation.

Main Methods:

  • Serial stool samples were collected from 24 preterm infants over 60 days of postnatal age.
  • Fecal calprotectin was measured before and after the initiation of human milk fortification.
  • Infant demographics, diet, and clinical data were recorded and analyzed.

Main Results:

  • Median fecal calprotectin levels remained similar before and after fortification.
  • Calprotectin levels were inversely correlated with postnatal age and positively with fortifier and antibiotic use.
  • After adjusting for postnatal age, fortifier and postnatal antibiotic use were associated with significantly lower calprotectin levels.

Conclusions:

  • The use of human milk fortifiers containing hydrolyzed protein is not associated with increased fecal calprotectin.
  • These findings suggest that hydrolyzed protein fortifiers are a safe option for preterm infants, without inducing intestinal inflammation markers.