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Efficacy of auranofin as demonstrated by improvement in clinical parameters and decrease in anti-inflammatory usage:

J C Brenol, W Chahade, G G De Freitas

    Scandinavian Journal of Rheumatology. Supplement
    |January 1, 1986
    PubMed
    Summary
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    Auranofin (AF) significantly improved rheumatoid arthritis (RA) symptoms over 24 months in Brazilian patients. This gold-based therapy demonstrated sustained efficacy and a manageable safety profile, reducing the need for other anti-inflammatory drugs.

    Area of Science:

    • Rheumatology
    • Pharmacology
    • Clinical Medicine

    Background:

    • Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint inflammation and progressive damage.
    • Gold-based therapies have been used in RA management, but their long-term efficacy and safety require ongoing evaluation.

    Purpose of the Study:

    • To assess the long-term efficacy and safety of auranofin (AF) in patients with rheumatoid arthritis (RA).
    • To evaluate the impact of AF on clinical parameters of disease activity and the requirement for concomitant anti-inflammatory drugs.

    Main Methods:

    • An open, noncomparative study conducted at 8 rheumatology centers in Brazil.
    • 80 patients with classic or definite RA received auranofin (3 mg twice daily) plus varying doses of anti-inflammatory drugs.

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  • Patients were followed for up to 24 months, with assessments of clinical parameters and adverse events.

    • Main Results:

    • Statistically significant improvements (p < 0.001) in 9 clinical parameters of RA disease activity were observed, starting within 3 months and sustained for 24 months.
    • Notable improvements included a 150% increase in well-being, a 66% decrease in pain intensity, and a 78% decrease in morning stiffness duration by 24 months.
    • The average daily dose of concomitant anti-inflammatory drugs decreased over the study period. 75% of patients completed 24 months of therapy.

    Conclusions:

    • Auranofin (AF) demonstrates significant and sustained efficacy in improving clinical parameters of rheumatoid arthritis (RA) over 24 months.
    • AF therapy led to a reduced need for other anti-inflammatory medications.
    • The safety profile of AF was consistent with previous trials, with adverse events including diarrhea and proteinuria, leading to withdrawal in 12.5% of patients.