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Updated: Dec 7, 2025

Controlling the Size, Shape and Stability of Supramolecular Polymers in Water
Published on: August 2, 2012
Hydrophobicity-driven folding and seeded polymerization of cystine-based dimeric diamides in aqueous media
Natsumi Fukaya1, Soichiro Ogi1, Midori Kawashiro1
1Department of Chemistry, Graduate School of Science, and Integrated Research Consortium on Chemical Sciences (IRCCS), Nagoya University, Furo, Chikusa, Nagoya, 464-8602, Japan. ogi.soichiro@chem.nagoya-u.ac.jp yamaguchi@chem.nagoya-u.ac.jp.
Abstract:
Seeded supramolecular polymerization of cystine-based dimeric diamides with aromatic substituents at the C- and N-termini was achieved in aqueous media. Theoretical and spectroscopic studies reveal that the terminal groups play crucial roles in slowing spontaneous assembly through formation of a folded conformation and guiding molecular alignment in the aggregated state.
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