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Published on: November 9, 2019
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2-Activated 1,3-enynes in enantioselective synthesis
Xiaoze Bao1, Jinhui Ren1, Yang Yang1
1College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China. hongw@zjut.edu.cn baoxiaoze@zjut.edu.cn.
Organic & Biomolecular Chemistry
|September 30, 2020
Summary
This review details the development of 2-activated 1,3-enyne as a key building block for enantioselective synthesis. It highlights its use in creating valuable pharmaceutical compounds and privileged scaffolds.
Area of Science:
- Organic Chemistry
- Asymmetric Synthesis
Background:
- Enantioselective synthesis is crucial for creating valuable building blocks and pharmaceutical compounds.
- 2-Activated 1,3-enyne is a versatile synthon for constructing complex molecules.
Purpose of the Study:
- To review the historical development of 2-activated 1,3-enyne in enantioselective synthesis.
- To explore the mechanisms involved in these synthetic transformations.
- To inspire future research in synthesizing complex molecules.
Main Methods:
- Review of literature on enantioselective synthesis using 2-activated 1,3-enyne.
- Analysis of reaction mechanisms for key transformations.
Main Results:
- 2-Activated 1,3-enyne enables efficient synthesis of enantioenriched furans, allenes, 4-H-pyrans, and 4-isoxazolines.
- These heterocyclic compounds are privileged scaffolds in numerous bioactive molecules and natural products.
Conclusions:
- 2-Activated 1,3-enyne is a powerful tool in modern organic synthesis.
- Further development in this area can lead to the creation of more complex and valuable molecules.
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