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Asthma: Pathogenesis and Management

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.

Asthma-IV: Diagnostic and Management

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:

Asthma-II: Pathophysiology and Classification

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

Asthma-III: Symptoms and Complications

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma

Asthma-I: Introduction

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...

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Updated: Dec 7, 2025

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Advances and recent developments in asthma in 2020.

Lacin Cevhertas^1,2,3, Ismail Ogulur^1,4, Debbie J Maurer¹

¹Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.

|September 30, 2020

Summary

This summary is machine-generated.

This review covers asthma prevalence, risk factors, and prevention, exploring genetic, epigenetic, and environmental influences. It details advanced diagnostics, personalized treatments, and the impact of COVID-19 on asthma management.

Keywords:

COVID-19 asthma biomarkers asthma phenotypes biological therapeutics comorbidities

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Last Updated: Dec 7, 2025

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

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Area of Science:

Pulmonology and Allergy
Immunology
Environmental Health

Background:

Asthma is a complex respiratory condition influenced by numerous factors.
Understanding its development requires examining genetic, epigenetic, and environmental interactions.
The exposome paradigm offers a framework for studying these influences.

Purpose of the Study:

To review recent publications on asthma.
To synthesize current knowledge on asthma prevalence, risk factors, mechanisms, diagnosis, and treatment.
To explore emerging concepts and challenges in asthma research and management.

Main Methods:

Comprehensive literature review of recent asthma publications.
Analysis of studies on risk factors, molecular mechanisms, and immune responses.
Critical appraisal of diagnostic and therapeutic strategies, including biologics.
Examination of the interplay between asthma, comorbidities, and COVID-19.

Main Results:

Asthma development involves complex interactions of genetic, epigenetic, microbial, and environmental factors.
Advances in understanding molecular and immune mechanisms offer potential new therapeutic targets.
Accurate diagnosis, endotyping, and comorbidity management are crucial for precision medicine in asthma.
Novel treatments, particularly biologics, show promise for specific asthma endotypes.

Conclusions:

Integrated approaches considering the exposome are vital for asthma research.
Precision medicine, guided by endotyping and biomarkers, is advancing asthma care.
The relationship between asthma, allergies, and COVID-19 requires further investigation for effective patient management.