A prospective multicentre external validation study of the Liverpool Peritonsillar abscess Score (LPS) with a
David Selwyn1, Ding Yang2, Elliot Heward3
1Bradford Royal Infirmary, Bradford, UK.
Objectives:
Our primary aim was to validate the Liverpool Peritonsillar abscess Score (LPS) externally in a new patient cohort. Our secondary aim was to modify the LPS in the light of the COVID-19 pandemic to produce a no-examination variant for use in this instance.
Design:
Prospective multicentre external validation study.
Setting:
Six different secondary care institutions across the United Kingdom.
Participants:
Patients over 16 years old who were referred to ENT with any uncomplicated sore throat such a tonsillitis or peritonsillar abscess (PTA).
Main Outcome Measures:
Sensitivity, specificity, positive predictive value and negative predictive value for both the original LPS model and the modified model for COVID-19.
Results:
The LPS model had sensitivity and specificity calculated at 98% and 79%, respectively. The LPS has a high negative predictive value (NPV) of 99%. The positive predictive value (PPV) was slightly lower at 63%. Receiver operating characteristic (ROC) curve, including the area under the curve (AUROC), was 0.888 which indicates very good accuracy.
Conclusions:
External validation of the LPS against an independent geographically diverse population yields high NPV. This may support non-specialist colleagues who may have concerns about mis-diagnosing a PTA. The COVID-19 modification of the LPS has a similar NPV, which may be of use where routine oral examination is to be avoided during the COVID-19 pandemic.
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