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Published on: March 27, 2018
Incidence, Characteristics, and Outcomes of Emergent Isolated Coronary Artery Bypass Grafting
Mohamed Farouk Elsisy1, John M Stulak2, Mohamad Alkhouli2
1Department of Cardiovascular Surgery, Mayo Clinic School of Medicine, Rochester, Minnesota.
Insights
The incidence of emergency coronary artery bypass surgery (CABG) significantly decreased from 1993 to 2019, particularly for cases arising from percutaneous coronary intervention complications. Despite advancements, in-hospital mortality for emergent CABG remained stable.
Area of Science:
- Cardiovascular Surgery
- Interventional Cardiology
- Health Outcomes Research
Background:
- Emergency coronary artery bypass surgery (CABG) data are scarce, necessitating analysis of trends and outcomes.
- Understanding the evolution of emergent CABG indications and patient profiles is crucial for surgical practice.
- The study examines a large cohort over an extended period to identify changes in emergent CABG procedures.
Purpose of the Study:
- To analyze trends in the incidence and indications of emergent isolated CABG.
- To evaluate in-hospital outcomes and long-term survival associated with emergent CABG.
- To compare patient characteristics and procedural outcomes across different time eras.
Main Methods:
- Retrospective analysis of 14,455 isolated CABG patients at Mayo Clinic (1993-2019).
- Categorization of emergent CABG cases into three eras: 1993-2000, 2001-2010, and 2011-2019.
- Kaplan-Meier survival analysis stratified by indication; comparison of baseline characteristics and in-hospital outcomes.
Main Results:
- The incidence of emergent CABG decreased from 2.95% overall to 55 cases in the latest era (2011-2019).
- A decline in emergent CABG due to failed percutaneous coronary intervention was observed (38.2% to 22.7%).
- Internal mammary graft use increased to 100% in the recent era; operative mortality was 8.7% overall, with no significant temporal increase, though renal failure incidence rose.
Conclusions:
- A significant temporal decrease in emergent CABG incidence was observed, linked to improved percutaneous coronary intervention outcomes.
- Despite increased heart failure prevalence and complete revascularization, in-hospital mortality for emergent CABG did not rise.
- Long-term survival was consistent across different emergent CABG indications.
Abstract:
Data on emergency coronary artery bypass surgery (CABG) are limited. We studied patients who underwent isolated CABG at Mayo Clinic between 1993 and 2019. Baseline characteristics and in-hospital outcomes of emergent CABG were described in consecutive eras (1993 to 2000, 2001 to 2010, and 2011 to 2019). Cumulative survival was estimated by the Kaplan Meier method for the overall group, and stratified by the indication of surgery. In the 14,455 isolated CABG included, 427 (2.95%) were emergent. The number of emergent CABG decreased from 222 to 150 and 55 in the consecutive study eras. There was a temporal increase in the prevalence of heart failure, but no change in mean age, and prevalence of hypertension, diabetes, renal failure, or atrial fibrillation. The proportion of patients with failed/complicated percutaneous coronary intervention decreased from 38.2% in 1993 to 2000 to 22.7% in 2001 to 2010 and 25.5% in 2011 to 2019 (p = 0.003). In 2011 to 2019, 100% of patient received an internal mammary graft compared with 75.6% in 1993 to 2000 (p < 0.001). Operative mortality was 8.7% overall (8.6% in 1993 to 2000, 10.0% in 2001 to 2010, and 5.5% in 2011 to 2019, p = 0.56). There were no differences in postoperative complications except for the incidence of renal failure and new dialysis which increased over time. Predicted 10-year survival was 57.0% and was not different according to CABG indication (p = 0.12). In conclusion, we documented a temporal decrease in the incidence of emergent CABG between 1993 and 2019, especially those performed due to complications of coronary interventions. Despite the higher prevalence of left ventricular dysfunction and the more complete revascularization in more recent years, in-hospital mortality did not increase.
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