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Skin microbiota as a therapeutic target for psoriasis treatment: Trends and perspectives

Roberta B Rigon1, Andréa C P de Freitas1, Juliano L Bicas2

  • 1Faculty of Pharmaceutical Sciences, University of Campinas (UNICAMP), Campinas, Brazil.

Journal of Cosmetic Dermatology
|September 30, 2020
PubMed

Insights

Probiotics may help manage psoriasis by supporting skin health. This review compiles clinical trials on probiotic therapy for psoriasis patients, highlighting their potential therapeutic benefits.

Area of Science:

  • Dermatology
  • Microbiology
  • Immunology

Background:

  • Psoriasis is a chronic, immune-mediated skin condition significantly impacting quality of life.
  • The skin microbiota's role in psoriasis pathogenesis and immune regulation is increasingly recognized.
  • Clinical evidence for pre-, pro-, and synbiotics in psoriasis management remains limited.

Purpose of the Study:

  • To review the role of probiotic microorganisms in maintaining skin homeostasis.
  • To compile and analyze existing clinical trials on probiotic therapy for psoriasis.
  • To highlight probiotics as a potential therapeutic avenue in dermatology.

Main Methods:

  • Systematic literature search for clinical trials involving probiotics and psoriasis.
  • Analysis of studies focusing on probiotic mechanisms in skin health.
  • Synthesis of findings on the efficacy of probiotic interventions.

Main Results:

  • Probiotic microorganisms show potential in contributing to skin homeostasis.
  • Compiled clinical trials demonstrate a positive effect of probiotic therapy in psoriasis patients.
  • This review serves as the first compilation of such clinical data.

Conclusions:

  • Probiotic therapy presents a promising area for scientific exploration in psoriasis management.
  • Further clinical research is warranted to establish definitive therapeutic guidelines.
  • Integrating probiotics may offer a novel approach to improving patient outcomes in psoriasis.
Keywords:
dysbiosisprebioticsprobioticspsoriasisskin microbiota

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