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Fibril-associated Collagen

Fibril-associated Collagen

Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...

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Updated: Dec 7, 2025

Production of Nanofibrillar Patterned Collagen for Tissue Engineering

Production of Nanofibrillar Patterned Collagen for Tissue Engineering

Published on: September 20, 2024

Fish Collagen: Extraction, Characterization, and Applications for Biomaterials Engineering.

Hafez Jafari¹, Alberto Lista², Manuela Mafosso Siekapen³

¹BioMatter Unit-BTL, École Polytechnique de Bruxelles, Université Libre de Bruxelles, Avenue F.D. Roosevelt, 50-CP 165/61, 1050 Brussels, Belgium.

|October 1, 2020

Summary

This summary is machine-generated.

Marine collagen, derived from fish by-products, offers unique advantages over mammalian collagen. This review covers recent extraction methods and biomedical applications of marine collagen.

Keywords:

collagen extraction deep eutectic solvent fish collagen medical applications

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Area of Science:

Biomaterials Science
Biochemistry
Marine Biotechnology

Background:

Marine collagen utilization is increasing due to superior properties like biocompatibility and disease-free sourcing compared to mammalian collagen.
Fish by-products are a sustainable and cost-effective source for marine collagen extraction.
Recent research (2014-2020) focuses on optimizing marine collagen extraction and exploring its applications.

Purpose of the Study:

To provide an overview of recent studies on marine collagen extraction from fish by-products (2014-2020).
To detail and compare collagen structure, extraction methodologies, characterization techniques, and biomedical applications.
To investigate the influence of extraction parameters on collagen yield.

Main Methods:

Review of scientific literature from 2014 to 2020 focusing on marine collagen.
Detailed description and comparison of acetic acid and deep eutectic solvent (DES) extraction methods.
Analysis of the impact of temperature, acid concentration, extraction time, and solid-to-liquid ratio on collagen yield.

Main Results:

Marine collagen exhibits advantageous properties including low molecular weight, high biocompatibility, and ease of absorption.
Acetic acid and DES methods are effective for marine collagen isolation, with varying impacts on yield based on parameters.
Extraction parameters significantly influence the yield of collagen from fish by-products.

Conclusions:

Marine collagen is a promising biomaterial with diverse biomedical and therapeutic applications.
Optimized extraction techniques enhance the yield and quality of marine collagen.
Fish-derived collagen represents a sustainable and valuable alternative to mammalian collagen.