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Sperm impairing microbial factor: potential candidate for male contraception
Aditi Chauhan1, Deepali Thaper1, Vijay Prabha2
1Department of Microbiology, Panjab University, Chandigarh, 160014, India.
Reproductive Biology and Endocrinology : RB&E
|October 1, 2020
Summary
A novel microbial factor, SIF, administered into the vas deferens, induced temporary azoospermia (no sperm) in male mice, showing potential as a reversible male contraceptive. This offers a new avenue for male birth control development.
Area of Science:
- Reproductive Biology
- Microbiology
- Pharmacology
Background:
- Limited male contraceptive options necessitate new methods.
- Microbial products show promise for contraception.
- Staphylococcus aureus-derived Sperm Immobilization Factor (SIF) demonstrated prior female contraceptive efficacy.
Purpose of the Study:
- To evaluate Sperm Immobilization Factor (SIF) as a potential male contraceptive.
- To assess the efficacy and safety of SIF administered via the vas deferens in a mouse model.
Main Methods:
- SIF was administered into the vas deferens of male mice.
- Various doses of SIF and a SIF binding receptor were tested.
- Evaluated parameters included body weight, seminal parameters, testosterone levels, and histology.
Main Results:
- Intra-vas deferens SIF administration led to azoospermia lasting up to 90 days.
- Testosterone levels decreased, and testicular histology showed hypospermatogenesis and maturation arrest.
- Azoospermia was reversible with administration of a SIF binding receptor.
Conclusions:
- Intra-vas deferens SIF administration is a viable route for male contraception.
- SIF demonstrates potential as a safe and effective reversible male contraceptive agent.
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