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Next-generation Sequencing of Cerebrospinal Fluid: How Can a Liquid be Like a Solid?

Melina E Marmarelis1, Joshua M Bauml2

  • 1Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|October 1, 2020
PubMed

Abstract:

The APOLLO investigators showed that next-generation sequencing of cerebrospinal fluid can reveal molecular alterations-how should this affect our management approach?See related article by Xing et al., p. 6168.

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Cerebrospinal fluid (CSF) is a colorless liquid that flows around the brain and the spinal cord, playing a vital role in the protection, support, and overall function of the central nervous system (CNS). CSF production, circulation, and absorption are tightly regulated processes essential for the brain and spinal cord to function properly.
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