Related Experiment Video
Updated: Dec 7, 2025
Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases
Published on: June 14, 2021
A Human Amniotic Membrane Plug to Treat Persistent Macular Hole
Luca Ventre1, Paola Marolo1, Michele Reibaldi1
1Eye Clinic Section, Department of Surgical Sciences, University of Turin, Turin, Italy.
Human amniotic membrane (hAM) plugs show potential for treating persistent macular holes. Proper sizing of the hAM plug is crucial for anatomical closure and visual recovery in macular hole surgery.
Area of Science:
- Ophthalmology
- Regenerative Medicine
- Biomaterials
Background:
- Persistent macular holes remain a significant challenge in ophthalmic treatment.
- Human amniotic membrane (hAM) is emerging as a promising biomaterial for retinal applications.
Observation:
- A case study details the use of a 1.5 mm hAM plug in a 657 μm persistent macular hole via 23-G pars plana vitrectomy.
- Postoperative assessments included visual acuity and optical coherence tomography (OCT) at multiple follow-up intervals.
Findings:
- Initial OCT scans at 1 week showed no neuroretinal adhesion over the hAM plug.
- Subsequent OCT scans revealed reattachment of macular hole margins with partial neuroretinal ingrowth.
- Visual acuity improved from logMAR 1.0 (1 ETDRS letter) preoperatively to logMAR 0.9 (9-10 ETDRS letters) by 6-10 weeks post-surgery.
Implications:
- The precise adaptation of hAM plug size to the macular hole dimensions is critical for successful anatomical closure.
- This surgical approach highlights the importance of size matching for achieving potential functional outcomes in macular hole repair.
More Related Videos
07:48Engineering Transplantation-suitable Retinal Pigment Epithelium Tissue Derived from Human Embryonic Stem Cells
Published on: September 6, 2018
11:42Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration
Published on: September 12, 2014