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Enzyme-Regulated Healable Polymeric Hydrogels.

Panpan Li1, Yuanbo Zhong1, Xu Wang1

  • 1National Engineering Research Center for Colloidal Materials, School of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong 250100, China.

ACS Central Science
|October 1, 2020
PubMed
Summary
This summary is machine-generated.

Enzyme-regulated healable polymeric hydrogels offer self-repair capabilities through enzymatic reactions. This review summarizes advancements in bioinspired enzyme-regulated hydrogel systems for future development.

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Area of Science:

  • Polymer Science
  • Biomaterials Engineering
  • Biochemistry

Background:

  • Enzyme-regulated healable polymeric hydrogels are advanced soft materials with self-repair properties.
  • Enzymatic reactions control the fabrication, self-healing, and degradation of these hydrogels.
  • Current synthetic enzyme-regulated hydrogels lack the sophistication of biological systems.

Purpose of the Study:

  • To provide a systematic summary of current achievements in enzyme-regulated healable polymeric hydrogels.
  • To offer prospects for the future development of this rapidly advancing field.
  • To review bioinspired enzyme-regulated self-healing polymeric hydrogel systems.

Main Methods:

  • Review of literature on enzymatic fabrication and degradation of healable polymeric hydrogels.
  • Analysis of enzymatically regulated self-healing mechanisms in polymeric hydrogels.
  • Discussion of the functions and applications of these advanced materials.

Main Results:

  • Significant progress has been made in controlling hydrogel cross-linking and de-cross-linking using enzyme-catalyzed reactions.
  • The field of substrate-specific regulation of healable polymeric hydrogels is still in its early stages.
  • Bioinspired approaches show promise for enhancing the intelligence and practicality of these materials.

Conclusions:

  • Enzyme-regulated healable polymeric hydrogels represent a promising area of materials science with potential for diverse applications.
  • Further research is needed to bridge the gap between synthetic materials and the capabilities of living organisms.
  • This review highlights key developments and future directions for designing sophisticated self-healing hydrogel systems.