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Related Experiment Video

Updated: Dec 7, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
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An ace model for SARS-CoV-2 infection.

Jack Major1, Andreas Wack1

  • 1Immunoregulation Laboratory, The Francis Crick Institute, London, UK.

The Journal of Experimental Medicine
|October 1, 2020
PubMed
Summary

Researchers developed a new mouse model for SARS-CoV-2 infection to study COVID-19 progression. This model helps characterize the type I interferon-driven pulmonary inflammation associated with the disease.

Area of Science:

  • Virology
  • Immunology
  • Pathology

Background:

  • Effective in vivo models are essential for understanding SARS-CoV-2 infection and COVID-19 pathogenesis.
  • Previous models may not fully recapitulate key aspects of human disease progression.

Purpose of the Study:

  • To develop and validate a novel mouse model that supports SARS-CoV-2 infection.
  • To utilize this model for characterizing the pulmonary inflammatory response driven by type I interferons.

Main Methods:

  • Generation of a SARS-CoV-2 infection model in mice.
  • Characterization of the host immune response, focusing on pulmonary inflammation.

Main Results:

  • The developed mouse model supports SARS-CoV-2 infection, enabling in vivo studies.

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  • The model was used to characterize type I interferon-driven pulmonary inflammation during infection.

    • Conclusions:

    • This new mouse model provides a valuable tool for mechanistic studies of COVID-19.
    • It facilitates the investigation of host-pathogen interactions and inflammatory pathways in SARS-CoV-2 infection.