Related Experiment Video

Updated: Dec 7, 2025

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
08:12

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer

Published on: March 14, 2019

5.8K

Circular RNAs in gastrointestinal cancer: Current knowledge, biomarkers and targeted therapy (Review)

Xiaorui Zhao1, Yue Wang1, Qiongfang Yu2

  • 1Department of Pathogen Biology and Immunology, Medical College of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.

International Journal of Molecular Medicine
|October 1, 2020
PubMed

Insights

Circular RNAs (circRNAs) are novel non-coding RNAs with roles in cancer. This review summarizes circRNA biogenesis, function, and involvement in gastrointestinal cancer pathways, highlighting their diagnostic and therapeutic potential.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Circular RNAs (circRNAs) are endogenous non-coding RNAs formed by exon or intron cyclization.
  • They are stable, conserved, and specifically expressed in mammalian cells.
  • circRNAs can act as microRNA sponges, regulating gene expression and influencing biological processes like tumor progression.

Purpose of the Study:

  • To review the biogenesis, classification, and functions of circRNAs in tumors.
  • To discuss the role of circRNAs in signal transduction pathways relevant to gastrointestinal cancer.
  • To highlight the potential of circRNAs as biomarkers and therapeutic targets in cancer.

Main Methods:

  • Literature review of circRNAs in cancer.
  • Analysis of circRNA biogenesis and regulatory mechanisms.
  • Discussion of circRNA involvement in gastrointestinal cancer signaling pathways.

Main Results:

  • circRNAs play significant roles in tumor proliferation, invasion, metastasis, and apoptosis.
  • Specific circRNAs are implicated in various gastrointestinal cancer cellular functions.
  • circRNAs demonstrate potential for clinical diagnosis and treatment of gastrointestinal cancers.

Conclusions:

  • circRNAs are crucial regulators in tumorigenesis and cancer progression.
  • Understanding circRNA functions in gastrointestinal cancer offers new avenues for therapeutic intervention.
  • circRNAs hold promise as diagnostic and therapeutic agents in oncology.

More Related Videos

Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer07:59

Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer

Published on: September 8, 2023

1.5K
Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT10:28

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Published on: January 22, 2018

11.4K

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.4K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.5K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.0K