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Updated: Dec 7, 2025

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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Sorting Nexin 27 as a potential target in G protein‑coupled receptor recycling for cancer therapy (Review)

Zixu Bao1, Shijun Zhou2, Haisheng Zhou1

  • 1Department of Biochemistry and Molecular Biology, Anhui Medical University, Hefei, Anhui 230032, P.R. China.

Oncology Reports
|October 1, 2020
PubMed

Insights

Sorting nexin 27 (SNX27) mediates the recycling of G protein-coupled receptors (GPCRs) from endosomes back to the cell surface. Aberrant SNX27-mediated GPCR recycling is implicated in cancer development, suggesting SNX27 as a potential therapeutic target.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Oncology

Background:

  • G protein-coupled receptors (GPCRs) are crucial membrane proteins regulating cellular processes.
  • GPCRs undergo internalization and desensitization.
  • Sorting nexin 27 (SNX27) is a key regulator of protein trafficking via the retromer complex.

Purpose of the Study:

  • To investigate the role of SNX27 in GPCR recycling.
  • To explore the potential of SNX27 as a therapeutic target in cancer.

Main Methods:

  • Studies involving the interaction between GPCRs and SNX27.
  • Analysis of GPCRs C-terminal PDZ binding motifs.
  • Investigation of endosome-to-membrane recycling pathways.

Main Results:

  • SNX27 interacts with specific GPCRs containing PDZ binding motifs.
  • SNX27 facilitates the recycling of GPCRs from endosomes to the plasma membrane.
  • Aberrant SNX27-mediated GPCR recycling is linked to cancer progression.

Conclusions:

  • SNX27 plays a significant role in the functional recycling of GPCRs.
  • Dysregulated SNX27 activity in GPCR recycling may contribute to cancer.
  • SNX27 represents a promising novel target for cancer therapies.
Keywords:
SNX27G protein-coupled receptorscancertargeted therapy

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