Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cadherins in Tissue Organization01:19

Cadherins in Tissue Organization

3.7K
The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...
3.7K
Structure of Cadherins01:25

Structure of Cadherins

4.3K
The cadherins were one of the first cell adhesion molecules discovered; the term “cadherins”   is based on their calcium-dependent adhering properties. The first cadherins discovered on the epithelial, neuronal, and placental cells were named E-cadherin, P-cadherin, and N-cadherin, respectively. These classical cadherins share sequence and structural similarities. Other cadherins, including those involved in cell signaling, are grouped into non-classical cadherins. This...
4.3K
Catenins01:23

Catenins

2.8K
Catenins are characterized by multiple binding domains and dynamic structures that allow them to function as linker proteins in cell junction complexes. All catenins, except α-catenin, contain a characteristic protein sequence called the armadillo repeat and are therefore also called armadillo proteins.
Catenins in Cell Junctions
Catenins bind to cell adhesion molecules such as cadherins and link them to different cytoskeletal proteins depending on the type of cell junction. At the...
2.8K
Mechanism of Ciliary Motion01:05

Mechanism of Ciliary Motion

4.6K
The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
4.6K
Notch Signaling Pathway03:14

Notch Signaling Pathway

5.9K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
5.9K
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

9.3K
The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
9.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High-frequency spike inference with particle Gibbs sampling.

eLife·2026
Same author

High frequency spike inference with particle Gibbs sampling.

bioRxiv : the preprint server for biology·2026
Same author

Manipulating perceived postural stability in younger and older adults and the effect on standing postural stability and gait.

Neuroscience·2025
Same author

The comparative effect of exercise interventions on balance in perimenopausal and early postmenopausal women: A systematic review and network meta-analysis of randomised, controlled trials.

Maturitas·2023
Same author

Cognitive and visual task effects on gaze behaviour and gait of younger and older adults.

Experimental brain research·2023
Same author

The minimal important change for measures of balance and postural control in older adults: a systematic review.

Age and ageing·2022

Related Experiment Video

Updated: Dec 7, 2025

Ex Vivo Oculomotor Slice Culture from Embryonic GFP-Expressing Mice for Time-Lapse Imaging of Oculomotor Nerve Outgrowth
06:04

Ex Vivo Oculomotor Slice Culture from Embryonic GFP-Expressing Mice for Time-Lapse Imaging of Oculomotor Nerve Outgrowth

Published on: July 16, 2019

8.9K

Cadherins regulate nuclear topography and function of developing ocular motor circuitry.

Athene Knüfer1, Giovanni Diana1, Gregory S Walsh2

  • 1Centre for Developmental Neurobiology, King's College London, London, United Kingdom.

Elife
|October 1, 2020
PubMed
Summary

Cadherins guide neuron positioning in the brain, forming organized nuclei essential for motor function. Disrupting this cell adhesion impacts neuronal migration and visual reflexes in zebrafish.

Keywords:
brainstemcadherinscell adhesiondevelopmental biologymotor neuronneuroscienceocular motor systemoculomotorzebrafish

More Related Videos

4-Dimensional Imaging of Zebrafish Optic Cup Morphogenesis
07:26

4-Dimensional Imaging of Zebrafish Optic Cup Morphogenesis

Published on: May 26, 2021

3.7K
Using Primary Neurosphere Cultures to Study Primary Cilia
08:14

Using Primary Neurosphere Cultures to Study Primary Cilia

Published on: April 14, 2017

9.6K

Related Experiment Videos

Last Updated: Dec 7, 2025

Ex Vivo Oculomotor Slice Culture from Embryonic GFP-Expressing Mice for Time-Lapse Imaging of Oculomotor Nerve Outgrowth
06:04

Ex Vivo Oculomotor Slice Culture from Embryonic GFP-Expressing Mice for Time-Lapse Imaging of Oculomotor Nerve Outgrowth

Published on: July 16, 2019

8.9K
4-Dimensional Imaging of Zebrafish Optic Cup Morphogenesis
07:26

4-Dimensional Imaging of Zebrafish Optic Cup Morphogenesis

Published on: May 26, 2021

3.7K
Using Primary Neurosphere Cultures to Study Primary Cilia
08:14

Using Primary Neurosphere Cultures to Study Primary Cilia

Published on: April 14, 2017

9.6K

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Molecular Biology

Background:

  • Cranial motor neurons in vertebrates form organized nuclei, but the molecular mechanisms are unclear.
  • Understanding nuclear topography is crucial for comprehending circuit function.

Purpose of the Study:

  • Investigate the role of cadherin-mediated adhesion in the development of zebrafish ocular motor nuclei.
  • Elucidate how cadherins contribute to neuronal positioning and subnuclear organization.

Main Methods:

  • Studied differential expression of classical cadherins in developing ocular motor nuclei.
  • Perturbed cadherin function in neurons to observe effects on positioning and migration.
  • Assessed the impact of cadherin disruption on larval optokinetic reflex.

Main Results:

  • Developing ocular motor nuclei show differential cadherin expression.
  • Cadherin disruption caused neuronal scattering and defective migration of subnuclei.
  • Cadherin interactions between subnuclei are vital for their position.
  • Impaired cadherin adhesivity in dorsal oculomotor neurons disrupted the optokinetic reflex.

Conclusions:

  • Cadherins are critical regulators of cranial motor neuron positioning.
  • Cadherin-mediated adhesion establishes subnuclear topography and influences motor circuit function.