Inflammation-responsive nanocapsules for the dual-release of antibacterial drugs
Arjaree Jobdeedamrong1, Man Theerasilp, Nattarat Wongsuwan
1Department of Materials Science and Engineering, School of Molecular Science and Engineering, Vidyasirimedhi Institute of Science and Technology, 21210 Rayong, Thailand.
Chemical Communications (Cambridge, England)
|October 1, 2020
Abstract:
Herein, we design inflammation-responsive nanocapsules containing two antibiotics. The releases are programmed to be triggered under conditions occurring at the different stages of wound healing. The nanocapsules exhibit excellent antibacterial activities against Gram-positive, Gram-negative, and antibiotic-resistant bacteria. Incorporation of small amounts of nanocapsules in hydrogels leads to efficient antibacterial wound dressings.
