Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Retrovirus Life Cycles01:10

Retrovirus Life Cycles

48.8K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
48.8K
The Antiviral System of Bacteria and Archaea: CRISPR01:23

The Antiviral System of Bacteria and Archaea: CRISPR

484
CRISPR stands for Clustered Regularly Interspaced Short Palindromic Repeats is a adaptive immune system found in bacteria and archaea that protects against viral infections. This system enables prokaryotic cells to identify, remember, and neutralize foreign genetic elements, primarily bacteriophages, by storing fragments of the invader’s DNA as a genetic memory.The CRISPR immune response begins during an initial infection. Cas (CRISPR-associated) proteins play a central role in this...
484
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

1.5K
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Microneedle-based bioassays.

Nanoscale advances·2022
Same author

pH-Responsive doxorubicin delivery using shear-thinning biomaterials for localized melanoma treatment.

Nanoscale·2021
Same author

Combinatorial screening of biochemical and physical signals for phenotypic regulation of stem cell-based cartilage tissue engineering.

Science advances·2020
Same author

CRISPR-Cas12a delivery by DNA-mediated bioresponsive editing for cholesterol regulation.

Science advances·2020
Same author

A Perspective on 3D Bioprinting in Tissue Regeneration.

Bio-design and manufacturing·2019
Same author

Sutureless repair of corneal injuries using naturally derived bioadhesive hydrogels.

Science advances·2019
Same journal

Engineered Young Brown Adipose Tissue-Derived Exosomes Alleviate Radiation-Induced Lung Injury by Promoting G Protein-Coupled Receptor 183 Ubiquitination.

ACS nano·2026
Same journal

Pore Geometry-Driven Capture of Trace Aromatic Volatile Organic Compounds in Al-Based MOFs.

ACS nano·2026
Same journal

Dual-Bridged Porphyrin-Based Covalent Organic Framework with Integrated Specific Fluorescent Recognition and Cooperative Adsorption Capabilities.

ACS nano·2026
Same journal

Split-Gate Memtransistors for Energy-Efficient Adaptive Reinforcement Learning.

ACS nano·2026
Same journal

Interface Coordination Nucleation of Copper Nanoclusters on Covalent Organic Frameworks for Electrocatalytic Ammonia Synthesis.

ACS nano·2026
Same journal

High-Performance Near-Infrared Quantum Emission from Color Centers in hBN.

ACS nano·2026
See all related articles

Related Experiment Video

Updated: Dec 7, 2025

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds
09:29

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds

Published on: October 29, 2015

30.7K

Engineering Antiviral Vaccines.

Xingwu Zhou1,2,3, Xing Jiang4, Moyuan Qu5

  • 1Department of Bioengineering, University of California, Los Angeles, Los Angeles, California 90095, United States.

ACS Nano
|October 1, 2020
PubMed
Summary
This summary is machine-generated.

Developing new vaccines requires innovative approaches. This review explores advances in vaccine discovery, formulation, and delivery, focusing on biomaterials and nanotechnology for faster, more effective immunization strategies against viral diseases.

Keywords:
COVID-19biomedical devicesdrug deliverydrug discoveryimmunotherapyinfectious diseasepandemicsvaccine

More Related Videos

Engineering Antiviral Agents via Surface Plasmon Resonance
13:00

Engineering Antiviral Agents via Surface Plasmon Resonance

Published on: June 14, 2022

2.6K
Assays for the Identification of Novel Antivirals against Bluetongue Virus
12:02

Assays for the Identification of Novel Antivirals against Bluetongue Virus

Published on: October 11, 2013

14.4K

Related Experiment Videos

Last Updated: Dec 7, 2025

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds
09:29

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds

Published on: October 29, 2015

30.7K
Engineering Antiviral Agents via Surface Plasmon Resonance
13:00

Engineering Antiviral Agents via Surface Plasmon Resonance

Published on: June 14, 2022

2.6K
Assays for the Identification of Novel Antivirals against Bluetongue Virus
12:02

Assays for the Identification of Novel Antivirals against Bluetongue Virus

Published on: October 11, 2013

14.4K

Area of Science:

  • Vaccinology
  • Biomaterials Science
  • Nanotechnology

Background:

  • Vaccines are crucial for combating viral pathogens, yet effective vaccines remain elusive for many diseases.
  • The COVID-19 pandemic highlighted challenges in rapid vaccine development and population-level immunization.
  • Advances in genomics, structural biology, and immunology offer new tools for vaccine design.

Purpose of the Study:

  • To review recent advancements in vaccine development, encompassing discovery, formulation, and delivery.
  • To highlight the role of alternative administration methods and enabling technologies.
  • To explore strategies for accelerating vaccine development, particularly during pandemics.

Main Methods:

  • Focus on vaccine discovery, formulation, and delivery devices.
  • Integration of biomaterials, biomolecular engineering, nanotechnology, and microfabrication.
  • Consideration of alternative administration approaches.

Main Results:

  • Exploration of novel vaccine discovery platforms.
  • Advancements in vaccine formulation for enhanced stability and efficacy.
  • Development of innovative delivery devices for alternative administration routes.
  • Integration of materials science and engineering for manufacturing and distribution.

Conclusions:

  • Biomaterials, nanotechnology, and microfabrication are key enablers for improved vaccine development.
  • Alternative administration approaches offer potential for faster and more efficient immunization.
  • Continued innovation is essential for addressing emerging infectious diseases and future pandemics.