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Prodrugs: My Initial Exploration and Where It Led.

Valentino J Stella1

  • 1Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, KS 66047, USA.

Journal of Pharmaceutical Sciences
|October 1, 2020
PubMed
Summary

This review explores prodrugs, focusing on phenytoin (diphenylhydantoin) prodrugs. Prodrug strategies are vital for developing challenging small molecule drugs.

Area of Science:

  • Medicinal Chemistry
  • Drug Development
  • Pharmacology

Background:

  • Prodrugs are modified drug forms enhancing delivery or efficacy.
  • Phenytoin (diphenylhydantoin) is a key anticonvulsant drug.
  • Developing challenging small molecules often requires prodrug approaches.

Purpose of the Study:

  • To review the early exploration of prodrugs.
  • To specifically examine prodrugs of the anticonvulsant phenytoin.
  • To provide insights into the utility of prodrug intervention.

Main Methods:

  • Literature review of prodrug strategies.
  • Focus on prodrug design for phenytoin.
  • Historical perspective on prodrug development.
Keywords:
FormulationLimitationsProdrugsSafetySolubilityStabilitySynthesis

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Main Results:

  • Prodrugs offer a valuable tool for drug development.
  • Prodrugs can transform un-developable drugs into viable therapeutics.
  • The exploration highlights the significance of prodrug interventions.

Conclusions:

  • Prodrugs are essential for overcoming challenges in small molecule drug development.
  • Phenytoin prodrugs represent a significant area of research.
  • Prodrug strategies continue to be a critical aspect of pharmaceutical science.