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Updated: Dec 7, 2025

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Flow Cytometric Analysis of Lymphocyte Infiltration in Central Nervous System during Experimental Autoimmune Encephalomyelitis
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A Rare Case of Cerebellar Progressive Multifocal Leukoencephalopathy due to Idiopathic CD4 Lymphocytopenia
Paige Sutton1, Flavius Raslau1, Padmaja Sudhakar1
1Neurology, 740 S. Limestone, J-455, Lexington, KY 40536, United States.
Multiple Sclerosis and Related Disorders
|October 1, 2020
Abstract:
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disorder caused by reactivation of JC virus during a time of cell mediated immune suppression. One potential rare cause of PML is Idiopathic CD4 lymphocytopenia (ICL) in which there is an unexplained deficit of CD4 T cells. We present a case of cerebellar PML in the absence of known immunosuppression leading to the diagnosis of ICL.

