Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

31.3K
Overview
31.3K
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

2.5K
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
2.5K
Allergic Drug Reactions01:27

Allergic Drug Reactions

1.2K
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.2K
Hypersensitivities01:30

Hypersensitivities

5.2K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
5.2K
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

1.6K
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
1.6K
Cross-reactivity00:42

Cross-reactivity

32.5K
Overview
32.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The long-term effectiveness of specific immunotherapy in cat allergy: a real-life study.

Immunotherapy·2026
Same author

Successful oral desensitization to temozolomide in a patient with immediate hypersensitivity reaction.

Cancer chemotherapy and pharmacology·2026
Same author

Immunonutrition in Early Life: The Role of Complementary Feeding, Dietary Patterns, and Nutritional Exposures on the Health of Young Children-An EAACI Scoping Review.

Allergy·2026
Same author

Bridging Rare to Common Diseases: Precision Medicine and the Transforming Landscape of Pediatric Allergy and Immunology.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology·2026
Same author

Redefining asthma through new immune response pattern: A clinically driven perspective.

Respiratory medicine·2026
Same author

Metabolomic Changes Following Oral Immunotherapy in Multi-Food Allergic Children.

Allergy·2026

Related Experiment Video

Updated: Dec 7, 2025

Humanized Mediator Release Assay as a Read-Out for Allergen Potency
10:22

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

3.8K

Tolerance mechanisms in allergen immunotherapy.

Zeynep Celebi Sözener1,2, Dilsad Mungan2, Lacin Cevhertas1,3,4

  • 1Swiss Institute of Allergy and Asthma Research (SIAF), University Zurich, Davos, Switzerland.

Current Opinion in Allergy and Clinical Immunology
|October 1, 2020
PubMed
Summary

Allergen immunotherapy (AIT) restores immune tolerance by generating regulatory T cells and reducing allergic inflammation. Further research aims to identify biomarkers for optimal AIT candidate selection.

More Related Videos

Antigenic Liposomes for Generation of Disease-specific Antibodies
10:31

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

12.7K
Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

9.0K

Related Experiment Videos

Last Updated: Dec 7, 2025

Humanized Mediator Release Assay as a Read-Out for Allergen Potency
10:22

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

3.8K
Antigenic Liposomes for Generation of Disease-specific Antibodies
10:31

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

12.7K
Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

9.0K

Area of Science:

  • Immunology
  • Allergy Research
  • Tolerance Mechanisms

Background:

  • Allergen immunotherapy (AIT) is a unique treatment that modifies allergic disease progression by inducing immune tolerance.
  • Understanding tolerance mechanisms is crucial for developing novel vaccines targeting immune responses.

Purpose of the Study:

  • To review the mechanisms of immune tolerance induced by AIT.
  • To highlight recent findings on cellular and molecular changes during AIT.
  • To suggest future research directions for optimizing AIT.

Main Methods:

  • Review of current literature on allergen immunotherapy.
  • Analysis of cellular and molecular pathways involved in immune tolerance.
  • Identification of biomarkers associated with AIT efficacy.

Main Results:

  • AIT induces allergen-specific peripheral tolerance, characterized by regulatory T (Treg) cells and reduced Th2 cells.
  • Early AIT phases decrease mast cell/basophil activity and eosinophil inflammation.
  • AIT promotes regulatory B cells, IL-10, TGF-β, ILC2reg, and DCreg cells for tolerance induction.

Conclusions:

  • AIT effectively restores immune tolerance through various cellular and molecular mechanisms.
  • Identifying optimal biomarkers and targets is essential for selecting ideal AIT candidates.
  • Further research into tolerance mechanisms will advance vaccine development for allergic diseases.