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Association of Major Histocompatibility Complex Class I Related Chain A/B Positive Microparticles with Acute
Songpol Haohan1,2, Burabha Pussadhamma1,3, Amonrat Jumnainsong4,5
1Cardiovascular Research Group, Khon Kaen University, Khon Kaen 40002, Thailand.
Insights
Microparticles expressing Major histocompatibility complex class I related chain A and B (MICA/B+ MPs) are elevated in acute myocardial infarction (AMI) patients. These MICA/B+ MPs are associated with AMI presence and disease severity, potentially mediating cardiac damage.
Area of Science:
- Cardiovascular Biology
- Immunology
- Cellular Stress Response
Background:
- Atherosclerosis and coronary artery disease (CAD) involve cell activation and stress, leading to acute myocardial infarction (AMI).
- Major histocompatibility complex class I related chain A and B (MICA/B) are expressed on stressed cells and released as microparticles (MICA/B+ MPs).
Purpose of the Study:
- To investigate the association between MICA/B+ MPs and the presence of AMI.
- To explore the correlation of MICA/B+ MPs with AMI disease severity.
Main Methods:
- Quantified MICA/B+ MPs from endothelial cells, platelets, monocytes, neutrophils, and T lymphocytes using flow cytometry.
- Recruited 51 AMI patients and 46 age-matched controls for analysis.
Main Results:
- MICA/B+ MP levels were significantly increased in AMI patients versus controls.
- Multivariate regression revealed an independent association between MICA/B+ MPs and AMI (OR = 11.6).
- MICA/B+ MP levels were higher in ST-segment elevation myocardial infarction (STEMI) than non-STEMI (NSTEMI) patients, with an independent association with STEMI (OR = 4.1).
Conclusions:
- MICA/B+ MPs are significantly associated with AMI and its severity.
- These microparticles may play a role in the pathological processes of AMI or reflect underlying cellular activation.
Background:
Various cell types undergo activation and stress during atherosclerosis resulting in the development of acute myocardial infarction (AMI) in coronary artery disease (CAD). Major histocompatibility complex class I related chain A and B (MICA/B) can be expressed on the surface of activated and stressed cells and released into blood circulation in several forms including microparticles (MICA/B+ MPs) from various cell types. We aimed to investigate the association of these MICA/B+ MPs with the presence of AMI. Fifty-one AMI and 46 age-matched control subjects were recruited.
Methods:
Levels of MICA/B+ MPs derived from various parent cells including endothelial cells, platelets, monocytes, neutrophils, and T lymphocytes were determined by flow cytometry.
Results:
The levels and proportion of MICA/B+ MPs from all types of cell origin were significantly increased in AMI patients compared to those of the controls. A multivariate regression model showed an independent association between MICA/B+ MPs and AMI (OR = 11.6; 95% CI = 2.8, 47.3). Interestingly, based on the disease severity, we found that the levels of MICA/B+ MPs were significantly elevated in the ST-segment elevation myocardial infarction (STEMI) compared to the non-STEMI (NSTEMI) patients. Moreover, an independent association of MICA/B+ MPs with the occurrence of STEMI was also demonstrated (OR = 4.1; 95% CI = 1.5, 16.7).
Conclusions:
These results suggest that MICA/B+ MPs are associated with AMI and disease severity. They may act as mediators contributing to the pathological process of AMI. Alternatively, they are the results of various cell activations contributing to AMI.
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