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Related Experiment Video

Updated: Dec 7, 2025

Visualization of IL-22-expressing Lymphocytes Using Reporter Mice

Visualization of IL-22-expressing Lymphocytes Using Reporter Mice

Published on: January 25, 2017

Microbiota-Dependent Effects of IL-22.

Morsal Sabihi¹, Marius Böttcher¹, Penelope Pelczar¹

¹I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany.

|October 2, 2020

Summary

Interleukin-22 (IL-22) is crucial for barrier immunity but requires tight regulation. Dysregulated IL-22 contributes to autoimmunity and cancer, highlighting the need to understand its microbial interactions and clinical impact.

Keywords:

IL-22 IL-22BP IL-22R1 cytokines inflammation microbiota

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Published on: December 16, 2021

Area of Science:

Immunology
Microbiology
Epithelial Biology

Background:

Cytokines are vital for immune responses at epithelial barriers, protecting against pathogens and environmental threats.
Epithelial barriers require precise immune regulation to prevent invasion and control inflammation.
Interleukin-22 (IL-22) plays a key role in maintaining epithelial integrity, microbiota balance, and host defense.

Purpose of the Study:

To review novel findings on IL-22 and its interactions with microbial stimuli.
To elucidate the role of IL-22 in host defense and clinical outcomes.
To focus on the detrimental effects of dysregulated IL-22 control in disease.

Main Methods:

Literature review of recent research on IL-22.
Analysis of cytokine-microbe interactions at epithelial barriers.
Examination of IL-22's role in pathogenesis and disease progression.

Main Results:

IL-22 is essential for epithelial barrier function and defense against external threats.
Uncontrolled IL-22 production can promote autoimmunity and cancer development.
Specific microbial stimuli modulate IL-22 function with varying clinical consequences.

Conclusions:

Understanding IL-22's complex role, particularly its microbial interactions, is critical for managing diseases.
Tight regulation of IL-22 is necessary to harness its protective effects while preventing pathological outcomes.
Further research into IL-22 dysregulation is needed for therapeutic advancements in autoimmunity and cancer.