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Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
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Aortic stenosis calcium scoring in a racially mixed sample.

Daniel Brito1, Igor Goykhman2, Kevin Bryan Lo3

  • 1Institute for Heart and Vascular Health, Einstein Medical Center, Philadelphia, PA. BritoDan@einstein.edu.

Monaldi Archives for Chest Disease = Archivio Monaldi Per Le Malattie Del Torace
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Summary

Men with severe aortic stenosis (AS) show higher aortic valve calcification (AVC) than women, irrespective of race. This finding confirms previous research in Caucasian populations and highlights gender as a key factor in AS progression.

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Area of Science:

  • Cardiology
  • Radiology
  • Medical Imaging

Background:

  • Aortic stenosis (AS) is a growing concern with an aging population.
  • Previous studies suggest men have greater aortic valve calcification (AVC) than women in severe AS.
  • Existing data primarily focus on Caucasian populations, necessitating broader verification.

Purpose of the Study:

  • To investigate gender differences in AVC in severe AS patients.
  • To determine if these differences persist across racial subgroups.
  • To validate previous findings in a diverse patient cohort.

Main Methods:

  • Retrospective analysis of 137 severe AS patients undergoing valve replacement.
  • Computed tomography (CT) scans used to quantify aortic valve calcification (AVC) within six months of surgery.
  • Comparison of AVC scores between genders and across racial groups using statistical analysis.

Main Results:

  • Men exhibited significantly higher mean AVC scores (3646) compared to women (2433) (p=0.001).
  • Gender remained a significant predictor of AVC on multivariate analysis in the entire cohort and the non-Caucasian subgroup.
  • No significant difference in aortic valve area (AVA) indexed to body surface area (BSA) was observed between genders or racial groups.

Conclusions:

  • Men with severe AS consistently demonstrate higher AVC than women, regardless of their racial background.
  • These findings align with prior research conducted in predominantly Caucasian populations.
  • Gender is a significant factor influencing AVC accumulation in severe AS across diverse ethnicities.