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Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training
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Association between cardiac troponin I and mortality in patients with COVID-19

Michela Salvatici1, Barbara Barbieri1, Sara Maria Giulia Cioffi1

  • 1Laboratory Medicine, Humanitas Clinical and Research Center - IRCCS, Rozzano, Italy.

Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
|October 2, 2020
PubMed

Insights

High sensitivity cardiac troponin I (hs-TnI) levels are elevated in patients with severe Coronavirus Disease 2019 (COVID-19), indicating a worse prognosis. Elevated hs-TnI is a significant predictor of mortality in COVID-19 patients.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Biomarkers

Background:

  • Severe pneumonia is a manifestation of Coronavirus Disease 2019 (COVID-19).
  • Complications in COVID-19 patients are associated with a poorer prognosis.
  • The role of high sensitivity cardiac troponin I (hs-TnI) in SARS-CoV-2 infection requires evaluation.

Purpose of the Study:

  • To assess the prognostic value of hs-TnI in patients diagnosed with COVID-19.
  • To determine the correlation between hs-TnI levels and mortality in COVID-19 patients.

Main Methods:

  • Retrospective analysis of hs-TnI values in 523 COVID-19 patients admitted to a university hospital.
  • Median patient age was 64 years, with 68% males.
  • hs-TnI levels were measured and analyzed in relation to patient outcomes.

Main Results:

  • A significant difference in hs-TnI concentrations was observed between deceased and discharged patients (36.05 ng/L vs 6.3 ng/L, p < 0.001).
  • hs-TnI levels were independent predictors of mortality in multivariate analysis (HR 1.004, p < 0.001).
  • Survival rates varied significantly based on hs-TnI levels, with rates from 97.94% (under 6 ng/L) to 59.27% (over 40 ng/L).

Conclusions:

  • Elevated hs-TnI levels are associated with increased mortality in COVID-19 patients.
  • hs-TnI serves as a valuable biomarker for disease progression and prognosis in COVID-19.
  • Cardiac troponin monitoring can aid in risk stratification for COVID-19 patients.
Abstract

Keywords:
COVID-19cardiac troponinhospitalizationmortalityserially measurements of hs-TnI

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