Simple calculation using anatomical features on pre-treatment verification CT for bladder volume estimation during...

Despite detailed instruction for full bladder, patients are unable to maintain consistent bladder filling during a 5-week pelvic radiation therapy (RT) course. We investigated the best bladder volume estimation procedure for verifying consistent bladder volume.

We reviewed 462 patients who underwent pelvic RT. Biofeedback using a bladder scanner was conducted before simulation and during treatment. Exact bladder volume was calculated by bladder inner wall contour based on CT images (V_ctsim). Bladder volume was estimated either by bladder scanner (V_scan) or anatomical features from the presacral promontory to the bladder base and dome in the sagittal plane of CT (V_ratio). The feasibility of V_ratio was validated using daily megavoltage or kV cone-beam CT before treatment.

Mean V_ctsim was 335.6 ± 147.5 cc. Despite a positive correlation between V_ctsim and V_scan (R² = 0.278) and between V_ctsim and V_ratio (R² = 0.424), V_ratio yielded more consistent results than V_scan, with a mean percentage error of 26.3 (SD 19.6, p < 0.001). The correlation between V_ratio and V_ctsim was stronger than that between V_scan and V_ctsim (Z-score: - 7.782, p < 0.001). An accuracy of V_ratio was consistent in megavoltage or kV cone-beam CT during treatment. In a representative case, we can dichotomize for clinical scenarios with or without bowel displacement, using a ratio of 0.8 resulting in significant changes in bowel volume exposed to low radiation doses.

Bladder volume estimation using personalized anatomical features based on pre-treatment verification CT images was useful and more accurate than physician-dependent bladder scanners.

Retrospectively registered.