Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Fungal Phylum Microsporidia

Fungal Phylum Microsporidia

Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Harnessing generative artificial intelligence for periodontitis prediction: a machine learning approach integrating systemic health indicators for precision oral health in resource-limited settings.

Frontiers in dental medicine·2026

Same author

TGF-beta inhibitors influence leishmania infection outcome in a susceptible host.

Cytokine·2026

Same author

Bioinspired antimicrobial glass coatings for clear and infection-resistant surfaces.

Journal of materials chemistry. B·2026

Same author

Repurposing gabapentin and pregabalin to improve the anticancer efficacy of 5-fluorouracil through development of a dual-drug-loaded nanoformulation.

Naunyn-Schmiedeberg's archives of pharmacology·2026

Same author

Crystalline Dion-Jacobson 2D Layered Sn-Based Perovskites for Field-Effect Transistors.

Journal of the American Chemical Society·2026

Same author

Comparative proteomic profiling reveals distinct molecular signatures of drug resistance in clinical isolates of Leishmania donovani.

Parasitology international·2026

Search research articles

Related Experiment Video

Updated: Dec 7, 2025

In Vivo Infection with Leishmania amazonensis to Evaluate Parasite Virulence in Mice

In Vivo Infection with Leishmania amazonensis to Evaluate Parasite Virulence in Mice

Published on: February 20, 2020

Conundrums in leishmaniasis.

Baibaswata Saha¹, Surajit Bhattacharjee², Arup Sarkar³

¹Centre of Advanced Study, Department of Zoology, Savitribai Phule Pune University, Pune 411007, India.

|October 2, 2020

Summary

Leishmaniasis presents paradoxes, from sandfly saliva

Keywords:

Immune response Leishmaniasis PKDL Paradox T-cells

More Related Videos

In vivo Imaging of Transgenic Leishmania Parasites in a Live Host

In vivo Imaging of Transgenic Leishmania Parasites in a Live Host

Published on: July 27, 2010

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs

Published on: April 21, 2012

Related Experiment Videos

Last Updated: Dec 7, 2025

In Vivo Infection with Leishmania amazonensis to Evaluate Parasite Virulence in Mice

In Vivo Infection with Leishmania amazonensis to Evaluate Parasite Virulence in Mice

Published on: February 20, 2020

In vivo Imaging of Transgenic Leishmania Parasites in a Live Host

In vivo Imaging of Transgenic Leishmania Parasites in a Live Host

Published on: July 27, 2010

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs

Published on: April 21, 2012

Area of Science:

Immunology and Parasitology
Infectious Diseases

Background:

Leishmaniasis, caused by Leishmania parasites, presents complex immunological challenges.
The transmission by sandfly vectors and the host's immune response create unresolved paradoxes in disease progression and resolution.

Purpose of the Study:

To explore the immunological paradoxes in leishmaniasis, from initial skin infection to visceralization and post-treatment recurrence.
To understand the roles of neutrophils, macrophages, and T-helper cells in disease outcome and the pathogenesis of post-kala azar dermal leishmaniasis (PKDL).

Main Methods:

Review and synthesis of existing knowledge on the host-parasite interactions in leishmaniasis.
Analysis of immune cell dynamics, including neutrophils, macrophages, and T-cell subsets, during different stages of the disease.

Main Results:

Neutrophils can act as 'Trojan Horses,' facilitating parasite spread.
Granuloma formation serves dual roles in containment and immunopathogenesis.
T-helper cell differentiation paradoxically influences cure or non-cure outcomes in visceral leishmaniasis.

Conclusions:

Leishmaniasis pathogenesis is characterized by intricate immune responses and paradoxes.
Understanding these paradoxes is crucial for developing effective therapeutic strategies and managing disease recurrence like PKDL.