Related Experiment Video
Updated: Dec 7, 2025
08:07
Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility
Published on: April 5, 2024
1.2K
Endometriosis and Reproduction: What We Have Learned
Jaime Garcia-Fernandez1, Juan A García-Velasco2
1The University of Edinburgh Medical School, Edinburgh, UK.
The Yale Journal of Biology and Medicine
|October 2, 2020
Summary
Endometriosis primarily impacts ovarian reserve, potentially reducing egg count. Fertility preservation is crucial before ovarian surgery, as endometrial receptivity remains unaffected.
Area of Science:
- Reproductive Medicine
- Gynecology
- Infertility Research
Background:
- Endometriosis affects 10-15% of women of reproductive age.
- The disease's impact on fertility is complex and not fully understood.
- Assisted reproductive technologies offer insights into endometriosis-related infertility.
Purpose of the Study:
- To review the impact of endometriosis on ovarian reserve.
- To discuss surgical strategies for endometriosis, emphasizing ovarian damage.
- To highlight the importance of fertility preservation in endometriosis patients.
Main Methods:
- Mini-review of current literature.
- Analysis of data from assisted reproductive technology.
- Focus on ovarian quantitative impairment and endometrial receptivity.
Main Results:
- Endometriosis causes quantitative impairment of ovarian reserve.
- The "less is more" surgical approach is recommended for ovarian endometriosis.
- Fertility preservation should be considered before ovarian surgery.
- Endometrial receptivity is not significantly affected by endometriosis.
Conclusions:
- Ovarian damage is the primary fertility concern in endometriosis.
- Ovarian surgery for endometriosis requires careful consideration of ovarian reserve.
- Fertility preservation strategies are vital for women with endometriosis undergoing surgery.
Related Concept Videos
02:07Oogenesis
68.2K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
68.2K
01:27Ovarian Cycle
2.8K
The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle...
2.8K
01:24Disorders of the Female Reproductive System
3.7K
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
3.7K
01:22Hormonal Regulation of the Menstrual Cycle
1.2K
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
1.2K
01:28Infertility in Females
3.5K
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...
Endometriosis, a condition characterized by abnormal growth of...
3.5K
01:20Proliferative Phase
1.1K
The proliferative phase typically occurs after menstruation and lasts between 6 to 13 days in a standard 28-day cycle. This phase involves the reconstruction of the endometrium, guided by estrogen produced by the developing ovarian follicle.
Notably, the stratum basale, the basal layer of the endometrium, including the basal parts of the uterine glands, remains unaffected by menstruation. Stem cells in this layer undergo mitosis, regenerating the stratum functionalis and thickening the...
Notably, the stratum basale, the basal layer of the endometrium, including the basal parts of the uterine glands, remains unaffected by menstruation. Stem cells in this layer undergo mitosis, regenerating the stratum functionalis and thickening the...
1.1K