Long non-coding RNAs in prostate tumorigenesis and therapy (Review)
Ganggang Jiang1,2, Zhengming Su1,2, Xue Liang2
1Department of Urology, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510700, P.R. China.
Molecular and Clinical Oncology
|October 2, 2020
Summary
Long non-coding RNAs (lncRNAs) are key players in prostate cancer (PCa) development and progression. This review highlights their clinical utility and function in PCa, offering a guide for future research and treatment strategies.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Prostate cancer (PCa) is a common malignancy with incompletely understood mechanisms.
- Long non-coding RNAs (lncRNAs) are increasingly recognized as crucial in PCa biology.
- Dysregulated lncRNAs impact PCa risk stratification, diagnosis, and cancer development.
Purpose of the Study:
- To systematically review the clinical utility of lncRNAs in prostate cancer.
- To elucidate the functional roles of lncRNAs in prostate tumorigenesis.
- To provide a guide for understanding lncRNA involvement in PCa.
Main Methods:
- Systematic literature review.
- Analysis of accumulating evidence on lncRNA function in PCa.
- Exploration of lncRNA roles in pathways like androgen receptor interaction and PI3K/Akt signaling.
Main Results:
- lncRNAs are novel biomarkers associated with PCa.
- lncRNA dysregulation is linked to PCa risk, diagnosis, and carcinogenesis.
- lncRNAs influence prostate tumorigenesis via key signaling pathways.
Conclusions:
- lncRNAs hold significant potential as clinical biomarkers for PCa.
- Understanding lncRNA function offers novel therapeutic and diagnostic avenues for PCa.
- This review provides a comprehensive guide to lncRNA roles in prostate cancer.
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