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The Retinoblastoma Gene

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...

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Persistent Retinal Detachment in Retinoblastoma: The Challenges.

Sophia El Hamichi^1,2, Dhariana Acon², Veronica Kon Graversen¹

¹Miami Ocular Oncology and Retina, Miami, FL, USA.

Journal of Ophthalmology

|October 2, 2020

Summary

This summary is machine-generated.

Persistent retinal detachment (RD) occurs in 16% of retinoblastoma (RB) patients, often in advanced stages. Managing this complex condition presents a surgical dilemma due to poor visual prognosis.

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Establishment and Propagation of Human Retinoblastoma Tumors in Immune Deficient Mice

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Published on: August 4, 2011

Area of Science:

Ophthalmology
Pediatric Oncology
Retinal Diseases

Background:

Retinoblastoma (RB) is the most common pediatric eye tumor.
Advances in RB treatment aim to preserve the eye and vision.
Retinal detachment (RD) is a complication that can impair vision and treatment outcomes.

Purpose of the Study:

To investigate the incidence and characteristics of persistent retinal detachment (RD) in retinoblastoma (RB) patients.
To analyze factors associated with persistent RD after RB treatment.

Main Methods:

Retrospective review of 62 patients treated for RB between 2012 and 2019.
Analysis of eyes with persistent RD that did not resolve after complete tumor regression.
Evaluation of RB stage, RD characteristics, and treatment modalities.

Main Results:

Retinal detachment (RD) occurred in 67% of RB cases; 16% developed persistent RD.
Persistent RD was associated with advanced RB stages and complex RD components (exudative and tractional).
No eyes with persistent RD underwent surgical repair for the detachment.

Conclusions:

Persistent RD in retinoblastoma is linked to advanced disease and multifaceted retinal detachment.
The management of persistent RD in eyes with cancer and poor visual outcomes poses a significant clinical challenge.
Further research is needed to address the dilemma of surgical intervention in these complex cases.