Related Experiment Video

Updated: Dec 7, 2025

Author Spotlight: Advancing Cancer Associated Thrombosis Research in Rodent Models
04:40

Author Spotlight: Advancing Cancer Associated Thrombosis Research in Rodent Models

Published on: January 5, 2024

2.9K

COVID-19 Associated Coagulopathy in the Setting of Underlying Malignancy

Su Lin Lim1, Kok Hoe Chan1, Jihad Slim2

  • 1Internal Medicine, Saint Michael's Medical Center, Newark, USA.

Cureus
|October 2, 2020
PubMed

Insights

COVID-19 coagulopathy can cause dangerous blood clots like deep vein thrombosis (DVT) and pulmonary embolism (PE), even during anticoagulation therapy. This case highlights the unpredictable nature of COVID-19

Area of Science:

  • Hematology
  • Oncology
  • Infectious Diseases

Background:

  • COVID-19 is associated with coagulopathy, increasing risks of deep vein thrombosis (DVT) and pulmonary embolism (PE).
  • Current guidelines for therapeutic anticoagulation in COVID-19 patients are lacking.
  • Metastatic malignancies present a known thrombophilic state.

Observation:

  • A confirmed COVID-19 patient with metastatic ovarian cancer developed DVT and PE.
  • The patient was already receiving therapeutic anticoagulation at the time of presentation.

Findings:

  • This case demonstrates the unpredictable and severe coagulopathy associated with COVID-19.
  • COVID-19 may exacerbate the inherent thrombophilic state in patients with metastatic cancer.

Implications:

  • Highlights the challenges in managing anticoagulation for COVID-19 patients due to a lack of evidence-based guidelines.
  • Suggests a potential synergistic effect between COVID-19 and malignancy on thrombogenesis.
  • Emphasizes the need for individualized treatment strategies in complex cases.

Keywords:
covid-19 associated coagulopathydeep venous thrombosismetastatic ovarian cancerpulmonary embolism

More Related Videos

Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients04:56

Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients

Published on: August 4, 2023

1.1K
Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation04:37

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Published on: May 23, 2025

911

Related Concept Videos

Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
1.7K
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants01:18

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
1.7K
Coagulation01:06

Coagulation

Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
937
Coagulation01:09

Coagulation

The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
9.1K
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
1.3K
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
170