Exploring Graphene and MoS₂ Chips Based Surface Plasmon Resonance Biosensors for Diagnostic Applications

Area of Science:

• Materials Science
• Nanotechnology
• Biomedical Engineering

Background:

• Two-dimensional (2D) nanomaterials offer large surface area, high conductivity, and facile surface modification, making them attractive for biosensor development.
• Surface Plasmon Resonance (SPR) biosensors are widely used for label-free detection in diagnostic applications.

Purpose of the Study:

• To review the application of 2D nanomaterials in SPR biosensors for diagnostics.
• To highlight the impact of graphene and molybdenum disulfide (MoS2) on SPR biosensor performance, particularly sensitivity.

Main Methods:

• Review of existing literature on 2D nanomaterials and SPR biosensors.
• Analysis of the properties of graphene and MoS2 relevant to SPR biosensing.
• Discussion of recent diagnostic applications utilizing these nanomaterials.

Main Results:

• Graphene and MoS2 significantly enhance the sensitivity of SPR biosensors due to their unique electronic and surface properties.
• The large specific surface area and conductivity of these 2D materials facilitate improved signal transduction.
• Surface modification of 2D materials allows for tailored biorecognition element immobilization.

Conclusions:

• 2D nanomaterials, specifically graphene and MoS2, are promising for advancing SPR biosensor technology in diagnostics.
• Their integration into SPR platforms leads to more sensitive and efficient diagnostic tools.
• Further research into novel 2D materials and their integration holds potential for next-generation biosensing platforms.