The Toxicology Investigators Consortium Case Registry-the 2019 Annual Report

Area of Science:

• Medical Toxicology
• Clinical Data Analysis
• Public Health Surveillance

Background:

• The American College of Medical Toxicology established the Toxicology Investigators Consortium (ToxIC) Registry in 2010.
• The Registry systematically collects data from bedside medical toxicology consultations across participating sites.

Purpose of the Study:

• To report on the 2019 data and activity of the ToxIC Registry.
• To summarize key findings from 7,177 newly added cases.
• To analyze trends in medical toxicology consultations, including demographics, exposures, and outcomes.

Main Methods:

• Data extraction from the ToxIC database for cases entered between January 1 and December 31, 2019.
• Aggregation of detailed case information including demographics, exposure agents, clinical signs, treatments, and mortality.
• Sub-analyses focusing on self-harm, gender differences in substance use disorder, and addiction medicine/pain management consultations.

Main Results:

• Non-opioid analgesics were the most frequent agent class, followed by opioids and antidepressants.
• Acetaminophen remained the most commonly reported single agent.
• There were 91 fatalities (1.3% of cases), with trends largely consistent with previous years.

Conclusions:

• The 2019 ToxIC Registry data highlights persistent trends in medical toxicology consultations.
• Acetaminophen and non-opioid analgesics continue to be leading causes of consultations.
• Ongoing surveillance is crucial for understanding and addressing public health challenges related to toxic exposures.