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Synthesis and Testing of Supported Pt-Cu Solid Solution Nanoparticle Catalysts for Propane Dehydrogenation
Published on: July 18, 2017
Copper-Catalyzed Propargylation of Nitroalkanes
Raphael S Kim1, Linh V Dinh-Nguyen1, Kirk W Shimkin1
1Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States.
Abstract:
Using a commercially available, inexpensive, and abundant copper catalyst system, an efficient α-functionalization of nitroalkanes with propargyl bromides is now established. This mild and robust method is highly functional group tolerant and provides straightforward access to complex secondary and tertiary homopropargylic nitroalkanes. Moreover, the utility of these α-propargylated nitroalkanes is demonstrated through downstream functionalization to biologically relevant, five-membered N-heterocycles such as pyrroles and 2-pyrrolines.
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