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Hold on Tight: Lagging-Strand DNA Polymerases Synthesize Multiple Okazaki Fragments without Letting Go
Vanessa Kellner1, Duncan J Smith1
1Department of Biology, New York University, New York, NY, USA.
Molecular Cell
|October 2, 2020
Abstract:
Kapadia et al. (2020) use an innovative single-molecule imaging approach in yeast cells to measure chromatin association of individual replisome subunits, thereby challenging the notion that lagging-strand DNA polymerases frequently dissociate from replisomes during DNA replication in vivo.
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