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Updated: Dec 7, 2025

Lethality Bioassay Using Artemia salina L.
Published on: October 11, 2022
Terpenes isolated from Polyalthia simiarum and their cytotoxic activities
Xiao-Yan Duan1, Kun-Yuan Guo2, Dong-Jin Lv3
1Key Laboratory of Economic Plants and Biotechnology and Yunnan Key Laboratory for Wild Plant Resources, State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China; Institute of Chinese Herbal Medicine, Hubei Academy of Agricultural Sciences, Enshi, City, Hubei 445000, PR China.
Abstract:
Two new C31 triterpenes, polysimiaric acid A (1) and B (2) as well as one new clerodane diterpenoid, 16,16-dimethoxy-cleroda-3,13Z-dien-15-oic acid (3), together with six known compounds were isolated from Polyalthia simiarum. Their structures were determined by analysis of 1D and 2D NMR data. Three new compounds were tested for their cytotoxicity against five human tumour cell lines. Compound 3 showed cytotoxic activities against SMMC-7721 with the IC50 value of 22.43 μM.

