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Prominent roles of microRNA-142 in cancer

Yasamin Pahlavan1, Mina Mohammadi Nasr2, Elaheh Dalir Abdolahinia3

  • 1Deputy of Research and Technology, Ardabil University of Medical Sciences, Ardabil, Iran.

Pathology, Research and Practice
|October 2, 2020
PubMed

Insights

MicroRNAs regulate gene expression and are vital for development. Aberrant microRNA expression, like miR-142, is linked to cancer development and progression, impacting cell migration and apoptosis.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • MicroRNAs (miRNAs) are non-coding RNAs regulating gene expression post-transcriptionally.
  • Dysregulated miRNA expression is implicated in various pathological conditions, notably cancers.
  • MiRNAs can act as either tumor suppressors or oncogenes depending on cellular context.

Purpose of the Study:

  • To review the molecular mechanisms and expression status of miRNA-142.
  • To elucidate the role of miRNA-142 in the pathogenesis of different human cancers.

Main Methods:

  • Literature review of studies on miRNA-142.
  • Analysis of miRNA-142 expression patterns in various cancer types.
  • Discussion of molecular pathways targeted by miRNA-142.

Main Results:

  • miR-142, located at chromosome 17q22, is frequently dysregulated in cancers.
  • miR-142 influences key cellular processes including migration, proliferation, and apoptosis.
  • Its specific role (oncogenic or tumor-suppressive) varies across different cancer types.

Conclusions:

  • miR-142 is a significant player in cancer development and progression.
  • Understanding miR-142's molecular functions is crucial for cancer research.
  • Further investigation into miR-142's role may offer therapeutic insights.
Keywords:
CancerInvasionMalignanciesMetastasismiRNA-142

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