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Updated: Dec 7, 2025

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
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Published on: February 16, 2016

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Relationship between Semi-Quantitative Parameters of Thallium-201 Myocardial Perfusion Imaging and Coronary Artery

Chin-Chuan Chang1,2,3,4, Ming-Hui Yang5, Chih-Ting Liu1

  • 1Department of Nuclear Medicine, Kaohsiung Medical University Hospital, Kaohsiung 80756, Taiwan.

Diagnostics (Basel, Switzerland)
|October 3, 2020
PubMed

Insights

The stress total perfusion deficit (sTPD) parameter from thallium-201 myocardial perfusion imaging (MPI) effectively diagnoses coronary artery disease (CAD). An sTPD cutoff of 3.5% shows significant diagnostic performance in patients.

Area of Science:

  • Cardiology
  • Nuclear Medicine
  • Diagnostic Imaging

Background:

  • Coronary artery disease (CAD) diagnosis relies on accurate imaging techniques.
  • Thallium-201 myocardial perfusion imaging (MPI) is a key diagnostic tool.
  • Semi-quantitative parameters of MPI require further validation for CAD detection.

Purpose of the Study:

  • To evaluate the diagnostic performance of semi-quantitative parameters in thallium-201 MPI for CAD.
  • To identify optimal cutoff values for these parameters using ROC analysis.
  • To assess the clinical utility of stress total perfusion deficit (sTPD) in diagnosing CAD.

Main Methods:

  • Retrospective analysis of 130 patients undergoing Tl-201 MPI and cardiac catheterization.
  • Receiver operating characteristic (ROC) analysis to determine optimal cutoff values.
  • Comparison of sensitivity and specificity for various semi-quantitative parameters, including sTPD.

Main Results:

  • The stress total perfusion deficit (sTPD) demonstrated the highest area under the curve (0.813) at a cutoff of 3.5%.
  • sTPD achieved a sensitivity of 73.5% and specificity of 74.5% for CAD diagnosis (p=0.0000).
  • Subgroup analysis in diabetic or dyslipidemic patients yielded similar diagnostic performance.

Conclusions:

  • The sTPD parameter in Tl-201 MPI has a significant clinical role in diagnosing CAD.
  • A cutoff value of 3.5% for sTPD is recommended for CAD diagnosis based on current data.
  • Further validation under diverse image acquisition conditions may enhance clinical application.

Keywords:
coronary artery diseasemyocardial perfusion imagingsemi-quantitative parametersstress perfusion deficitthallium-201

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