Related Experiment Video

Updated: Dec 7, 2025

In situ Subcellular Fractionation of Adherent and Non-adherent Mammalian Cells
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Published on: July 23, 2010

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Role of Viral Ribonucleoproteins in Human Papillomavirus Type 16 Gene Expression

Naoko Kajitani1, Stefan Schwartz1

  • 1Department of Laboratory Medicine, Lund University, 22184 Lund, Sweden.

Viruses
|October 3, 2020
PubMed

Insights

Human papillomaviruses (HPVs) utilize cellular RNA processing, including splicing and polyadenylation, for gene expression. This review details how HPV16 RNA processing and interactions with cellular factors impact its life cycle and cancer development.

Area of Science:

  • Molecular Biology
  • Virology
  • Genetics

Background:

  • Human papillomaviruses (HPVs) rely on host cell RNA processing for gene expression.
  • Alternative splicing and polyadenylation are critical for HPV mRNA production.
  • Suboptimal HPV splice sites necessitate complex regulatory mechanisms.

Purpose of the Study:

  • To review the regulation of HPV16 gene expression at the RNA processing level.
  • To focus on the interactions between HPV16 pre-mRNAs and cellular RNA-binding factors.
  • To elucidate the role of RNA processing in HPV life cycle and cancer.

Main Methods:

  • Literature review of HPV RNA processing mechanisms.
  • Analysis of cis-regulatory elements and trans-acting factors.
  • Examination of HPV ribonucleoprotein complex formation.

Main Results:

  • HPV RNA processing is intricate due to overlapping coding sequences and variable exon/intron definitions.
  • Cellular RNA-binding proteins play a crucial role in modulating HPV gene expression outcomes.
  • Dysregulation of HPV RNA processing contributes to HPV-associated cancers.

Conclusions:

  • Cellular RNA processing machinery is essential for HPV gene expression control.
  • Interactions between HPV16 pre-mRNAs and host factors dictate viral gene expression.
  • Understanding these interactions is key to targeting HPV-driven diseases.
Keywords:
SR proteinshnRNPhuman papillomavirus (HPV)papillomaviruspolyadenylationsplicing

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