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Postbiotics against Pathogens Commonly Involved in Pediatric Infectious Diseases

Anastasia Mantziari1, Seppo Salminen1, Hania Szajewska2

  • 1Functional Foods Forum, Faculty of Medicine, University of Turku, 20520 Turku, Finland.

Microorganisms
|October 3, 2020
PubMed

Insights

Postbiotics, compounds from fermentation, may help prevent infections in children under five. These biotherapeutics support the immune system and intestinal health, offering a safe alternative for pediatric care.

Area of Science:

  • Pediatric Health
  • Immunology
  • Microbiology

Background:

  • Infant and perinatal mortality reduction is a global health priority.
  • Bioactive compounds and biotherapeutics like postbiotics are explored for immune system support.
  • Postbiotics, fermentation products, promote gut health and integrity with low risk for children.

Purpose of the Study:

  • To review the mechanisms of action of postbiotics.
  • To present evidence on postbiotic efficacy against common pediatric pathogens.
  • To explore postbiotics as a strategy for preventing childhood infections.

Main Methods:

  • Literature review of studies on postbiotics.
  • Analysis of postbiotic mechanisms of action.
  • Evaluation of evidence for postbiotic effects on pediatric pathogens.

Main Results:

  • Postbiotics can modulate cellular responses and stimulate humoral immunity.
  • Evidence suggests potential benefits against pathogens causing pediatric infections.
  • Postbiotics may enhance intestinal barrier function.

Conclusions:

  • Postbiotics show promise as a safe therapeutic strategy for pediatric infections.
  • Further research is needed to fully understand their role in child health.
  • Postbiotics could contribute to achieving Sustainable Development Goals related to child mortality.

Keywords:
childrencommon infectious diseasespostbioticsprobioticspublic health

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