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Published on: October 11, 2013
Antiviral effect of baicalin on Marek's disease virus in CEF cells
Fan Yang1,2,3, Chun Feng1,2,3, Yongxiu Yao4
1Ministry of Education Key Lab for Avian Preventive Medicine, Yangzhou University, No.48 East Wenhui Road, Yangzhou, Jiangsu, 225009, P.R. China.
Background:
Baicalin, the main metabolic component of Scutellaria baicalensis Georgi, has various pharmacological properties including anti-inflammatory, anti-oxidant, anti-apoptotic, anti-bactericidal and anti-viral. The purpose of this study was to investigate the anti-Marek's disease virus (MDV) activities of baicalin in CEF cells.
Results:
Here, we showed that baicalin could inhibit viral mRNA, protein levels and overall plaque formation in a time-dependent manner. We also found that baicalin could consistently inhibit MDV replication and directly affect the virus infectivity. Moreover, baicalin treatment has no effect on expression level of antiviral cytokine and inflammatory cytokines in MDV infected CEFs.
Conclusions:
These results demonstrate that baicalin could be a potential drug against MDV infection.
