Structural differences between male and female brains

Research based on structural magnetic resonance imaging (MRI) has revealed a number of sex differences in the anatomy of the human brain. The first part of this chapter presents an excerpt of these findings discriminating among effects on a global, regional, and local level. While findings are far from consistent and conclusive, there is general consensus with respect to sex-specific brain size, with male brains being bigger on average than female brains. So, the question arises as to whether any of the observed sex differences are merely driven by brain size. The second part of this chapter thus sheds light on a unique scientific attempt to discriminate between brain size effects and sex effects. The overarching goal of this chapter is to exemplify the variety of findings and to demonstrate that the presence, magnitude, and direction of significant sex differences strongly depend on the measurement applied. The assumption that sex differences are simply a by-product of brain size, rather than pure (size independent) sex effects has proven to be true for some but certainly not all findings. Therefore, when examining the possible sexual dimorphism of the brain, it is imperative to avoid oversimplification and generalization.