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Innovative Tools and Strategies for Optimizing Yeast Cell Factories
Gregory Guirimand1, Natalja Kulagina2, Nicolas Papon3
1Graduate School of Sciences, Technology and Innovation, Kobe University, Kobe, Japan; Biomolécules et Biotechnologies Végétales (BBV), Équipe d'Accueil (EA) 2106, Université de Tours, Tours, France.
Trends in Biotechnology
|October 3, 2020
Summary
Metabolic engineering advances yeast cell factories for high-yield compound production. Cutting-edge tools optimize pathways, control fluxes, and reconfigure metabolism for industrial applications.
Area of Science:
- Synthetic Biology
- Biotechnology
- Microbial Engineering
Background:
- Metabolic engineering (ME) focuses on creating efficient microbial cell factories.
- These factories are crucial for producing valuable compounds from diverse feedstocks.
- Yeast cell factories (YCFs) are key platforms in ME.
Purpose of the Study:
- To summarize recent advancements in ME methods for YCFs.
- To highlight cutting-edge molecular tools and strategies for YCF optimization.
- To discuss future challenges and perspectives in yeast ME.
Main Methods:
- Biosynthetic pathway optimization using genome-editing tools.
- Combinatorial transcriptional and post-transcriptional engineering (cis/trans regulators).
- Dynamic control of metabolic fluxes and spatial reconfiguration of pathways.
- Adaptive laboratory evolution (ALE) for yeast ME.
Main Results:
- Recent developments enable precise tailoring of yeast cell factories.
- Advanced tools facilitate optimization of biosynthetic pathways and metabolic flux.
- Strategies for dynamic control and spatial organization enhance production efficiency.
Conclusions:
- Significant progress has been made in yeast metabolic engineering.
- Cutting-edge tools offer new possibilities for designing YCFs.
- Further research, including ALE, is essential for advancing microbial cell factories.
