Related Experiment Video
Updated: Dec 7, 2025
06:26
Novel and Innovative Hybrid Technique for Type A Aortic Dissection
Published on: March 28, 2025
687
Of aortic valve and bleeding: Heyde's syndrome.
Giuseppe Famularo1, Marzia Marrollo1
1Internal Medicine and Gastroenterology, San Camillo Hospital, Rome, Italy.
The American Journal of Emergency Medicine
|October 3, 2020
Summary
Severe aortic stenosis can cause gastrointestinal bleeding due to angiodysplasia, a condition known as Heyde's syndrome. Trans-catheter aortic valve replacement (TAVR) effectively resolves bleeding in these patients.
Area of Science:
- Cardiology
- Gastroenterology
- Hematology
Background:
- Heyde's syndrome links aortic stenosis with gastrointestinal angiodysplasia and bleeding.
- It involves acquired type 2A von Willebrand syndrome due to high shear stress from the stenotic valve.
Observation:
- An 80-year-old woman with severe aortic stenosis presented with recurrent enterorrhagia and anemia.
- Capsule endoscopy revealed jejunal angiodysplasia, treated with argon plasma coagulation.
- The patient underwent successful trans-catheter aortic valve replacement (TAVR).
Findings:
- Post-TAVR, the patient experienced complete resolution of gastrointestinal bleeding at 1 and 3-month follow-ups.
- Von Willebrand factor (vWF) abnormalities, linked to stenosis severity, are crucial in angiodysplasia development.
- Valve replacement normalizes vWF and resolves bleeding.
Implications:
- TAVR is a viable and effective treatment for Heyde's syndrome, particularly in high-risk patients.
- Addressing the underlying valvular pathology is key to managing associated GI bleeding.
- This case highlights the successful management of severe Heyde's syndrome with TAVR.
More Related Videos
06:51Author Spotlight: Development of a Minimally Invasive Large-Animal Model for Reliable and Reproducible Cardiovascular Research
Published on: October 20, 2023
1.5K
07:41A Model of Reverse Vascular Remodeling in Pulmonary Hypertension Due to Left Heart Disease by Aortic Debanding in Rats
Published on: March 1, 2022
3.3K
Related Concept Videos
01:15Aortic Regurgitation I: Introduction
274
IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
274
01:22Aortic Regurgitation II: Clinical Features and Diagnostic Tests
242
Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
242
01:30Aneurysm I: Introduction
170
An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
170
01:26Aneurysm III: Interprofessional Care
148
Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
148
01:21Aneurysm II: Clinical Manifestations and Diagnostic Studies
111
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
111
01:24Disorders of Hemostasis
1.7K
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
1.7K