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Updated: Dec 7, 2025

Trichuris muris Infection: A Model of Type 2 Immunity and Inflammation in the Gut

Trichuris muris Infection: A Model of Type 2 Immunity and Inflammation in the Gut

Published on: May 24, 2011

Trilateral Relationship: Ascaris, Microbiota, and Host Cells.

Ankur Midha¹, Friederike Ebner¹, Josephine Schlosser-Brandenburg¹

¹Institute of Immunology, Freie Universität Berlin, Robert von Ostertag-Str. 7-13, D-14163 Berlin, Germany.

Trends in Parasitology

|October 3, 2020

Summary

Ascariasis, a global intestinal nematode infection, involves complex Ascaris migration through host tissues. Understanding Ascaris-microbe-host cell interactions is key to developing new treatments for this widespread parasitic disease.

Keywords:

Ascaris helminth host–parasite interactions microbiota nematode

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Last Updated: Dec 7, 2025

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Published on: March 18, 2020

Area of Science:

Parasitology
Microbiology
Immunology

Background:

Ascariasis is a prevalent intestinal nematode infection affecting humans and pigs globally.
The Ascaris parasite undergoes extensive tissue migration, from the intestine to the liver and lungs, before returning to the intestine.

Purpose of the Study:

To review the current understanding of the tripartite relationship between Ascaris, its associated microbial communities, and host cells.
To explore novel strategies targeting these interactions for controlling ascariasis in humans and livestock.

Main Methods:

Literature review of existing research on Ascaris biology, host-parasite interactions, and the role of the microbiome.
Analysis of studies investigating cellular and molecular mechanisms of Ascaris migration and immune evasion.

Main Results:

Ascaris interacts with a complex microbial environment within the host tissues during its migration.
These interactions influence both nematode survival and host immune responses.
Understanding these trilateral dynamics is crucial for effective disease control.

Conclusions:

The relationship between Ascaris, microbes, and host cells is intricate and critical to the parasite's lifecycle.
Targeting these interactions presents promising avenues for novel therapeutic and control strategies against ascariasis.